Insulin anticorps

N° du produit ABIN6297591

Cet anticorps anti-Insulin est un anticorps Souris Monoclonal détectant Insulin dans IHC. Adapté pour Humain, Porc, Souris, Boeuf (Vache) et Rat.

Aperçu rapide pour Insulin anticorps (ABIN6297591)

Antigène: Insulin (INS)

Reactivité: Humain, Porc, Souris, Boeuf (Vache), Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Insulin anticorps

Fonction: Mouse anti-Human/Cow Pig/Mouse/Rat Insulin Antibody [IHC only]

Specificité: Cytoplasmic

Purification: Recombinant INS protein was used as the immunogen for the Insulin antibody.

Immunogène: Recombinant INS protein was used as the immunogen for the Insulin antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: Insulin

Sujet:

Target Description: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Gene Symbol: INS

ID gène: 3630

UniProt: P01308

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation