Insulin anticorps (INS)

Details for Product anti-INS Antibody No. ABIN6297594
Antigène
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivité
Boeuf (Vache), Humain, Souris, Porc, Lapin
710
285
251
233
190
118
11
9
6
6
6
4
3
2
2
2
2
2
1
1
1
1
1
1
Hôte
Souris
548
203
46
4
2
1
Clonalité
Monoclonal
Conjugué
Cet anticorp Insulin est non-conjugé
39
29
24
15
13
13
8
8
8
8
8
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
332
231
202
167
158
137
106
66
61
36
31
29
29
28
20
18
6
5
4
4
4
3
2
2
2
1
1
1
1
1
Options
Fonction Mouse anti-Human/Cow/Pig/Rabbit/Mouse Insulin Antibody [Sodium Azide Free]
Immunogène Recombinant INS protein was used as the immunogen for the Insulin antibody.
Specificité Cytoplasmic
Purification Recombinant INS protein was used as the immunogen for the Insulin antibody.
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Insulin (INS Antibody Extrait)
Sujet

Target Description: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Gene Symbol: INS

ID gène 3630
UniProt P01308
Pathways Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Indications d'application Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Agent conservateur Azide free
Stock 4 °C,-20 °C
Stockage commentaire 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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