SYVN1 anticorps (N-Term)

N° du produit ABIN650702

Détail du produit anti-SYVN1 anticorps

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Épitope: AA 106-138, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYVN1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, X

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This HRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-138 amino acids from the N-terminal region of human HRD1.

Clone: RB15288

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SYVN1 (ABIN650702)

Di, Wang, Han, Fu, Duerfeldt, Blagg, Mu: "Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation." dans: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9526-39, (2016) (PubMed).

van den Boomen, Timms, Grice, Stagg, Skødt, Dougan, Nathan, Lehner: "TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11425-30, (2014) (PubMed).

Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: "Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6010-21, (2013) (PubMed).

Burr, van den Boomen, Bye, Antrobus, Wiertz, Lehner: "MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 35, pp. 14290-5, (2013) (PubMed).

Détails sur SYVN1

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Autre désignation: HRD1 (SYVN1 Produits)

Synonymes: anticorps DER3, anticorps HRD1, anticorps hrd1, anticorps 1200010C09Rik, anticorps AW211966, anticorps C85322, anticorps D530017H19Rik, anticorps Hrd1, anticorps RGD1310488, anticorps syvn1, anticorps syvn1-a, anticorps syvn1-b, anticorps wu:fk91f10, anticorps zgc:55735, anticorps zgc:77108, anticorps synoviolin 1, anticorps synovial apoptosis inhibitor 1, synoviolin, anticorps synoviolin 1 S homeolog, anticorps SYVN1, anticorps syvn1, anticorps Syvn1, anticorps syvn1.S

Sujet: HRD1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence.

Poids moléculaire: 67685

NCBI Accession: NP_115807, NP_757385

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling