SH2D1A anticorps

N° du produit ABIN6567141

Détail du produit anti-SH2D1A anticorps

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2D1A est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human SH2D1A

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SH2D1A

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Autre désignation: SH2D1A (SH2D1A Produits)

Synonymes: anticorps DSHP, anticorps EBVS, anticorps IMD5, anticorps LYP, anticorps MTCP1, anticorps SAP, anticorps SAP/SH2D1A, anticorps XLP, anticorps XLPD, anticorps RGD1562408, anticorps Gm686, anticorps SH2D1A, anticorps SH2 domain containing 1A, anticorps SH2D1A, anticorps Sh2d1a

Sujet:

Synonyms: DSHP,Duncan disease SH2 protein,Duncan disease SH2-protein,EBVS,IMD5,LYP,MTCP1,SAP,SAP/SH2D1A,SH2 domain containing 1A,SH2 domain protein 1A,SH2 domain-containing protein 1A,SH21A,SH2D1A,Signaling lymphocyte activation molecule associated protein,Signaling lymphocytic activation molecule-associated protein,SLAM associated protein,SLAM associated protein/SH2 domain protein 1A,SLAM-associated protein,T cell signal transduction molecule SAP,T-cell signal transduction molecule SAP,XLP,XLPD

Background: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 17kDa

Calculated_MW: 6kDa/8kDa/13kDa/14kDa

ID gène: 4068

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process