SMC1A anticorps

N° du produit ABIN5967613

Détail du produit anti-SMC1A anticorps

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Immunofluorescence (IF)

Purification: Affinity purification

Immunogène: Recombinant protein of human SMC1A

Isotype: IgG

Information d'application

Indications d'application: IF 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1A (SMC1A Produits)

Synonymes: anticorps CDLS2, anticorps DXS423E, anticorps SB1.8, anticorps SMC1, anticorps SMC1L1, anticorps SMC1alpha, anticorps SMCB, anticorps SMC-1A, anticorps NV15570, anticorps 5830426I24Rik, anticorps Sb1.8, anticorps Smc1, anticorps Smc1alpha, anticorps Smc1l1, anticorps Smcb, anticorps mKIAA0178, anticorps smc1, anticorps smc1a, anticorps smc1l1, anticorps xSMC1, anticorps smc1aa, anticorps structural maintenance of chromosomes 1A, anticorps structural maintenance of chromosomes 1A b, anticorps structural maintenance of chromosomes 1A L homeolog, anticorps SMC1A, anticorps smc1a, anticorps Smc1a, anticorps smc1ab, anticorps smc1a.L

Sujet:

Synonyms: Chromosome segregation protein SmcB,DXS423E,KIAA0178,MGC138332,Sb1.8,Segregation of mitotic chromosomes 1,SMC protein 1A,SMC-1-alpha,SMC-1A,SMC1 (structural maintenance of chromosomes 1 yeast) like 1,SMC1,SMC1 structural maintenance of chromosomes 1 like 1,SMC1A,SMC1A,SMC1alpha,SMC1L1,SMCB,Structural maintenance of chromosomes 1A,Structural maintenance of chromosomes protein 1A

Background: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire:

Calculated_MW: 143kDa

ID gène: 8243

UniProt: Q14683

Pathways: Stem Cell Maintenance