Recombinant BCL10 anticorps (AA 122-168)

N° du produit ABIN6654586

L’anticorps anti-BCL10 Monoclonal Lapin est utilisé pour la détection de BCL10 dans des échantillons de Humain. Il a été validé pour IF, FACS et IHC (p).

Aperçu rapide pour Recombinant BCL10 anticorps (AA 122-168) (ABIN6654586)

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL10 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: BL10-2988R

Détail du produit anti-BCL10 anticorps

Épitope: AA 122-168

Fonction: Recombinant Bcl10 Antibody (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogène: A portion of amino acids 122-168 from the human protein was used as the immunogen for this recombinant Bcl10 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant Bcl10 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Bcl10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur BCL10

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Autre désignation: Bcl10

Sujet: Bcl10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1,14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of Bcl10 was shown to induce NFkB activation in a NIK-dependent pathway. This antibody labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1,14) translocation, while 55 % of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins