GABRB1 anticorps (Cytoplasmic Loop)

N° du produit ABIN6658240

Détail du produit anti-GABRB1 anticorps

Antigène: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Épitope: Cytoplasmic Loop

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRB1 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat (Rattus)

Purification: Anti-GABA(A) Receptor beta 1 Antibody is directed against rat GABA(A) Receptor beta 1. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, non-human primate, Xenopus, and zebra fish.

Immunogène:

Immunogen: Anti-GABA(A) Receptor beta 1 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the beta 1 subunit.

Immunogen Type: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application:

Application Note: Anti-GABA(A) Receptor beta 1 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the beta 1 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Détails sur GABRB1

Antigène: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Autre désignation: GABA(A) Receptor beta 1 (GABRB1 Produits)

Synonymes: anticorps AW061132, anticorps B230208N19Rik, anticorps Gabrb-1, anticorps GARB1, anticorps si:dkey-20i10.4, anticorps gamma-aminobutyric acid type A receptor beta1 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, anticorps gamma-aminobutyric acid type A receptor beta 1 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, beta 1, anticorps GABRB1, anticorps Gabrb1, anticorps gabrb1

Sujet:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit ß-1,

Background: Anti-GABA(A) Receptor beta 1 Antibody detects GABA(A) Receptor beta 1. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 1 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB1

ID gène: 25450

UniProt: P15431