FZD5 anticorps (PE-Cy3)

N° du produit ABIN681864

Détail du produit anti-FZD5 anticorps (PE-Cy3)

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD5 est conjugé à/à la PE-Cy3

Application: Western Blotting (WB), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Frizzled 5

Isotype: IgG

Information d'application

Indications d'application: IF (p) (1:100-500)
Not yet tested in other applications. Optimal working dilutions must be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Protect from light.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FZD5

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Autre désignation: Frizzled 5 (FZD5 Produits)

Synonymes: anticorps C2orf31, anticorps HFZ5, anticorps 5330434N09Rik, anticorps AI427138, anticorps Fz-5, anticorps Fz5, anticorps mFz5, anticorps Xfz5, anticorps frizzled5, anticorps frizzled5a, anticorps fz5, anticorps fzd5-A, anticorps fz2, anticorps fz8c, anticorps fzd8c, anticorps zg02, anticorps frizzled class receptor 5, anticorps frizzled class receptor 5 S homeolog, anticorps FZD5, anticorps Fzd5, anticorps fzd5.S, anticorps fzd5

Sujet:

Synonyms: C2orf31, Frizzled homolog 5, Frizzled-5, Frizzled5, Fz 5, Fz-5, Fz5, FZD 5, hFz5, FZD5, FZD5_HUMAN, FzE 5, FzE5, HFZ 5, Seven transmembrane receptor frizzled 5, Wnt receptor, hFz8, Fz-8, Frizzled-8, FZD8.

Background: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Poids moléculaire: 62 kDa

ID gène: 7855, 8325

Pathways: Signalisation WNT