C1QA anticorps (AA 104-237)

N° du produit ABIN6936537

Détail du produit anti-C1QA anticorps

Antigène: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Épitope: AA 104-237

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C1QA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 104-237) of human C1QA protein (exact sequence is proprietary)

Clone: C1QA-2953

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human liver or kidney tissue (IHC). PC-3 cell lysate (WB).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur C1QA

Antigène: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Autre désignation: C1QA (C1QA Produits)

Synonymes: anticorps zgc:109903, anticorps C1QA, anticorps AI255395, anticorps C1q, anticorps complement C1q A chain, anticorps complement component 1, q subcomponent, A chain, anticorps complement component 1, q subcomponent, alpha polypeptide, anticorps C1QA, anticorps c1qa, anticorps C1qa

Sujet: Complement C1q subcomponent subunit A, Complement component 1 q subcomponent alpha polypeptide,C1QA / Complement C1q A-Chain
Cellular localisation: Secreted

Poids moléculaire: 29kDa

ID gène: 712, 632379

UniProt: P02745

Pathways: Système du Complément