C1QB anticorps (AA 41-188)

N° du produit ABIN6936541

Détail du produit anti-C1QB anticorps

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Épitope: AA 41-188

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C1QB est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)

Clone: C1QB-2961

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Human liver, kidney or brain tissue (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur C1QB

Antigène: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Autre désignation: C1QB (C1QB Produits)

Synonymes: anticorps complement C1q B chain, anticorps complement component 1, q subcomponent, beta polypeptide, anticorps C1QB, anticorps C1qb

Sujet: C1QB, Complement component 1 q subcomponent B chain, Complement component C1q B chain,C1QB / Complement C1q B-Chain
Cellular localisation: Cytoplasmic and Cell Surface

Poids moléculaire: 26-29kDa

ID gène: 713, 8986

UniProt: P02746

Pathways: Système du Complément