Gelsolin anticorps

N° du produit ABIN6937348

Détail du produit anti-Gelsolin anticorps

Antigène: Gelsolin (GSN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Gelsolin est non-conjugé

Application: Western Blotting (WB)

Specificité: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human full-length protein

Clone: CPTC-Gelsolin-1

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: MCF cell lysate, Tonsil.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Gelsolin

Antigène: Gelsolin (GSN)

Autre désignation: GSN (GSN Produits)

Synonymes: anticorps ADF, anticorps AGEL, anticorps CG1106, anticorps DGS, anticorps Dmel\\CG1106, anticorps gel, anticorps scin, anticorps cb107, anticorps gsn, anticorps sb:cb107, anticorps u-gelsolin, anticorps wu:fi16f06, anticorps gelsolin, anticorps Gelsolin, anticorps gelsolin S homeolog, anticorps gelsolin a, anticorps GSN, anticorps Gel, anticorps Gsn, anticorps gsn.S, anticorps gsn, anticorps gsna

Sujet: Actin depolymerizing factor, ADF, AGEL, Brevin, Gsn,Gelsolin / Actin-depolymerizing Factor
Cellular localisation: Cytoplasm and secreted

Poids moléculaire: 90kDa

ID gène: 2934, 522373

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy