HSPD1 anticorps

N° du produit ABIN6939670

Détail du produit anti-HSPD1 anticorps

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HSPD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human HSPD1 protein

Clone: CPTC-HSPD1-1

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: HEP-2, PC3 or HeLa cells. Breast or Colon Carcinoma.

Known Application: Flow Cytometry (1-2 μg/0.5 million cells in 0.1ml), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur HSPD1

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Autre désignation: HSPD1 (HSPD1 Produits)

Synonymes: anticorps CPN60, anticorps GROEL, anticorps HLD4, anticorps HSP-60, anticorps HSP60, anticorps HSP65, anticorps HuCHA60, anticorps SPG13, anticorps chaperonin, anticorps cpn60, anticorps groel, anticorps hld4, anticorps hsp60, anticorps hsp65, anticorps spg13, anticorps 60kDa, anticorps Hsp60, anticorps 12, anticorps BP5, anticorps CG12101, anticorps Cpn60, anticorps Dmel\\CG12101, anticorps Dmhsp60, anticorps G62, anticorps HSP60A, anticorps Hsp60A, anticorps IEF16, anticorps Mmp-P1, anticorps SSP 7506, anticorps d-hsp60, anticorps hsp60A, anticorps l(1)10Ac, anticorps l(1)BP5, anticorps l(1)G8, anticorps l(1)HM21, anticorps l(1)L12, anticorps l(1)dp025, anticorps cb863, anticorps fa04a05, anticorps fb22d10, anticorps fi27b05, anticorps id:ibd2197, anticorps sb:cb144, anticorps wu:fa04a05, anticorps wu:fb22d10, anticorps wu:fi04a12, anticorps wu:fi27b05, anticorps MIF4, anticorps MNA2, anticorps mopA, anticorps groL, anticorps crpA, anticorps Hspd1-30p, anticorps heat shock protein family D (Hsp60) member 1, anticorps heat shock protein family D (Hsp60) member 1 S homeolog, anticorps 60 kDa heat shock protein, mitochondrial, anticorps heat shock protein 1 (chaperonin), anticorps Heat shock protein 60A, anticorps heat shock 60 protein 1, anticorps chaperone ATPase HSP60, anticorps molecular chaperone GroEL, anticorps thermosome subunit, anticorps chaperonin GroEL, anticorps mitochondrial chaperonin, anticorps heat shock protein family D member 1, anticorps HSPD1, anticorps hspd1.S, anticorps hspd1, anticorps LOC100414401, anticorps Hspd1, anticorps Hsp60A, anticorps HSP60, anticorps groEL, anticorps MMP_RS07785, anticorps groEl, anticorps LOC100136430

Sujet: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes, and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60, combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix, classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for T cell recognition, as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells, and changes in its expression level may serve as a biomarker, as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development, especially with regard to urothelial carcinomas. In ovarian cancer, decreased expression of HSP60 correlates with aggressive tumor types, while overexpression is correlated with a better patient prognosis.

Poids moléculaire: 60kDa

ID gène: 3329

UniProt: P10809

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity