Recombinant Insulin anticorps

N° du produit ABIN6939798

Cet anticorps anti-Insulin est un anticorps Lapin Monoclonal détectant Insulin dans IHC et StM. Adapté pour Humain, Porc, Souris, Boeuf (Vache) et Lapin.

Aperçu rapide pour Recombinant Insulin anticorps (ABIN6939798)

Antigène: Insulin (INS)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Porc, Souris, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: IRDN-1980R

Détail du produit anti-Insulin anticorps

Specificité: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Purification: Purified by Protein A/G

Immunogène: Recombinant human full-length Insulin protein (IRDN)

Isotype: IgG

Information d'application

Indications d'application:

Positive Control: MIA PaCa-2 cells. Pancreas.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: INS

Poids moléculaire: 6kDa

ID gène: 3630

UniProt: P01308

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation