LIG1 anticorps
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- Antigène Voir toutes LIG1 Anticorps
- LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache)
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LIG1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Purification
- Purified by Protein A/G
- Immunogène
- Full-length native cow LIG1 protein
- Clone
- 1A9
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product LIG1 Anticorps primaire
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- Indications d'application
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Positive Control: MOLT-4, PC-3 or Jurkat cell lysates.
Known Application: Western Blot (0.5-1 μg/mL), ELISA, Immunoprecipitation,Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
- Autre désignation
- LIG1 (LIG1 Produits)
- Synonymes
- anticorps ATLIG1, anticorps DNA ligase 1, anticorps T6D22.23, anticorps ligI, anticorps AL033288, anticorps LigI, anticorps lig1, anticorps wu:fc54a11, anticorps DNA ligase 1, anticorps DNA ligase 1, putative, anticorps ligase I, DNA, ATP-dependent L homeolog, anticorps ligase I, DNA, ATP-dependent, anticorps LIG1, anticorps PB000674.02.0, anticorps PTRG_06243, anticorps PKH_140260, anticorps lig1.L, anticorps Lig1, anticorps lig-1, anticorps lig1
- Sujet
- DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.
- Poids moléculaire
- 133kDa
- ID gène
- 3978
- UniProt
- P18858
- Pathways
- Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA
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