KDM5A anticorps

N° du produit ABIN6943881

Détail du produit anti-KDM5A anticorps

Antigène: KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp KDM5A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human KDM5A aa 1500-1690

Clone: 1G8

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur KDM5A

Antigène: KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))

Autre désignation: KDM5A (KDM5A Produits)

Synonymes: anticorps Jarid1a, anticorps JARID1A, anticorps RBBP-2, anticorps RBBP2, anticorps RBP2, anticorps AA409370, anticorps C76986, anticorps Rbbp2, anticorps lysine demethylase 5A, anticorps lysine (K)-specific demethylase 5A, anticorps Kdm5a, anticorps KDM5A

Sujet:

Synonyms: Lysine-specific demethylase 5A, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, RBBP-2, KDM5A, JARID1A, RBBP2, RBP2

Background: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.

ID gène: 5927

UniProt: P29375

Pathways: Chromatin Binding, L'effet Warburg