HVEM anticorps (N-Term)

N° du produit ABIN6990624

Détail du produit anti-HVEM anticorps

Antigène: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Épitope: AA 20-70, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HVEM est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: Multiple isoforms of TNFRSF14 are known to exist.

Purification: TNFRSF14 Antibody is affinity chromatography purified via peptide column.

Immunogène: TNFRSF14 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human TNFRSF14. The immunogen is located within amino acids 20 - 70 of TNFRSF14.

Isotype: IgG

Information d'application

Indications d'application: TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TNFRSF14 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TNFRSF14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur HVEM

Antigène: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Autre désignation: TNFRSF14 (TNFRSF14 Produits)

Synonymes: anticorps ATAR, anticorps CD270, anticorps HVEA, anticorps HVEM, anticorps LIGHTR, anticorps TR2, anticorps Atar, anticorps HveA, anticorps Hvem, anticorps Tnfrs14, anticorps TNF receptor superfamily member 14, anticorps tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator), anticorps Tnfrsf14, anticorps TNFRSF14

Classe de substances: Viral Protein

Sujet: TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κ,B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.

Poids moléculaire: Predicted: 20, 22, 29, 31 kDa

Observed: 23 kDa

ID gène: 8764

UniProt: Q92956

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints