ATP2C1 anticorps (C-Term)

N° du produit ABIN6991521

Détail du produit anti-ATP2C1 anticorps

Antigène: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2C1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: At least four isoforms of ATP2C1 are known to exist, this antibody will recognize only the three longest isoforms. ATP2C1 antibody will not cross-react with ATP2C2.

Purification: ATP2C1 Antibody is affinity chromatography purified via peptide column.

Immunogène: ATP2C1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ATP2C1. The immunogen is located within the last 50 amino acids of ATP2C1.

Isotype: IgG

Information d'application

Indications d'application: ATP2C1 antibody can be used for detection of ATP2C1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATP2C1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ATP2C1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ATP2C1

Antigène: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Autre désignation: ATP2C1 (ATP2C1 Produits)

Synonymes: anticorps ATP2C1, anticorps ATP2C1A, anticorps BCPM, anticorps HHD, anticorps PMR1, anticorps SPCA1, anticorps hSPCA1, anticorps Spca1, anticorps si:dkey-11p23.6, anticorps SPCA, anticorps 1700121J11Rik, anticorps AW061228, anticorps D930003G21Rik, anticorps pmr1, anticorps ATPase secretory pathway Ca2+ transporting 1, anticorps ATPase, Ca++ transporting, type 2C, member 1, anticorps ATPase, Ca++-sequestering, anticorps ATP2C1, anticorps atp2c1, anticorps Atp2c1

Sujet: ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

ID gène: 27032

NCBI Accession: NP_001001486

UniProt: P98194

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process