HRAS anticorps (C-Term)

N° du produit ABIN6991870

Cet anticorps Lapin Polyclonal détecte spécifiquement HRAS dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HRAS anticorps (C-Term) (ABIN6991870)

Antigène: HRAS (HRas proto-oncogene, GTPase (HRAS))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HRAS est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HRAS anticorps

Épitope: C-Term

Specificité: N-RAS antibody is predicted to not cross-react with H-RAS

Purification: N-RAS Antibody is affinity chromatography purified via peptide column.

Immunogène: N-RAS antibody was raised against a 15 amino acid peptide near the carboxy terminus of human N-RAS. The immunogen is located within the last 50 amino acids of N-RAS.

Isotype: IgG

Information d'application

Indications d'application: N-RAS antibody can be used for detection of N-RAS by Western blot at 1 and 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: N-RAS Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: N-RAS antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur HRAS

Antigène: HRAS (HRas proto-oncogene, GTPase (HRAS))

Autre désignation: N-RAS

Sujet: N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Poids moléculaire: Predicted: 22 kDa

Observed: 22 kDa

ID gène: 4893

NCBI Accession: NP_002515

UniProt: P01111

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling, BCR Signaling