VISTA anticorps (C-Term)

N° du produit ABIN6992209

Détail du produit anti-VISTA anticorps

Antigène: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VISTA est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Purification: VISTA Antibody is affinity chromatography purified via peptide column.

Immunogène: VISTA antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human VISTA. The immunogen is located within the last 60 amino acids of VISTA.

Isotype: IgG

Information d'application

Indications d'application: VISTA antibody can be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL. For Immunocytochemistry start at 1 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: VISTA Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: VISTA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur VISTA

Antigène: VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))

Autre désignation: VISTA (VISTA Produits)

Synonymes: anticorps MGC112715, anticorps MGC151567, anticorps B7-H5, anticorps B7H5, anticorps GI24, anticorps PP2135, anticorps SISP1, anticorps Dies1, anticorps VISTA, anticorps V-set immunoregulatory receptor, anticorps vsir, anticorps Vsir, anticorps VSIR

Sujet: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).

ID gène: 64115

NCBI Accession: NP_071436

UniProt: Q9H7M9

Pathways: Cancer Immune Checkpoints