TIM3 anticorps (Extracellular Domain) (Biotin)

N° du produit ABIN6992273

Détail du produit anti-TIM3 anticorps (Biotin)

Antigène: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIM3 est conjugé à/à la Biotin

Application: ELISA

Purification: TIM-3 Antibody is supplied as protein A purified IgG1.

Immunogène: TIM-3 antibody was raised against the extracellular domain of human TIM-3

Clone: 10C10

Isotype: IgG1 kappa

Information d'application

Indications d'application: TIM-3 antibody can be used for ELISA starting at 0.1 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TIM-3 Antibody is supplied in PBS containing 1 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TIM-3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TIM3

Antigène: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Autre désignation: TIM3 (TIM 3 Produits)

Synonymes: anticorps HAVCR2, anticorps MGC140131, anticorps HAVcr-2, anticorps KIM-3, anticorps TIM3, anticorps TIMD-3, anticorps TIMD3, anticorps Tim-3, anticorps TIM-3, anticorps Tim3, anticorps Timd3, anticorps tim3, anticorps hepatitis A virus cellular receptor 2, anticorps HAVCR2, anticorps Havcr2

Classe de substances: Virus

Sujet: The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-? producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice, blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

ID gène: 84868

NCBI Accession: NP_116171

UniProt: Q8TDQ0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints