anticorps AW208791, anticorps Mint-3, anticorps X11gamma, anticorps lin-10, anticorps mint3, anticorps MGC:15815, anticorps X11L2, anticorps Mint3, anticorps amyloid beta precursor protein binding family A member 3, anticorps amyloid beta (A4) precursor protein-binding, family A, member 3, anticorps APBA3, anticorps Apba3
Sujet
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).