KIAA1524 anticorps

N° du produit ABIN7074432

Détail du produit anti-KIAA1524 anticorps

Antigène: KIAA1524

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIAA1524 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse CIP2A

Information d'application

Indications d'application: WB (H,M,R) 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur KIAA1524

Antigène: KIAA1524

Autre désignation: CIP2A (KIAA1524 Produits)

Synonymes: anticorps CIP2A, anticorps p90, anticorps AA408511, anticorps AU018569, anticorps Cip2a, anticorps Kiaa1524, anticorps KIAA1524, anticorps LOC100222895, anticorps RGD1310335, anticorps cell proliferation regulating inhibitor of protein phosphatase 2A, anticorps RIKEN cDNA C330027C09 gene, anticorps KIAA1524, anticorps cell proliferation regulating inhibitor of protein phosphatase 2A L homeolog, anticorps CONSTANS interacting protein 2a, anticorps CIP2A, anticorps C330027C09Rik, anticorps KIAA1524, anticorps cip2a.L, anticorps CIP2a, anticorps cip2a, anticorps Cip2a

Sujet: Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Poids moléculaire: 102 kDa

ID gène: 224171

NCBI Accession: NP_766204

UniProt: Q8BWY9