MAML1 anticorps

N° du produit ABIN7074560

Détail du produit anti-MAML1 anticorps

Antigène: MAML1 (Mastermind-Like 1 (MAML1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAML1 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse MAML1

Information d'application

Indications d'application: WB (H,M) 1: 500-1: 1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur MAML1

Antigène: MAML1 (Mastermind-Like 1 (MAML1))

Autre désignation: MAML1 (MAML1 Produits)

Synonymes: anticorps mam1, anticorps mam-1, anticorps xmam1, anticorps MAML1, anticorps AI644666, anticorps AW743257, anticorps D930008C07Rik, anticorps Mam-1, anticorps Mam1, anticorps mKIAA0200, anticorps mastermind like transcriptional coactivator 1 L homeolog, anticorps mastermind like transcriptional coactivator 1, anticorps mastermind like 1 (Drosophila), anticorps mastermind-like transcriptional coactivator 1, anticorps maml1.L, anticorps MAML1, anticorps Maml1

Sujet: MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.

Poids moléculaire: 130 kDa

ID gène: 103806

NCBI Accession: NP_780543

UniProt: Q6T264

Pathways: Signalisation Notch, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development