TOP3A anticorps

N° du produit ABIN7075939

Détail du produit anti-TOP3A anticorps

Antigène: TOP3A (Topoisomerase (DNA) III alpha (TOP3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOP3A est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse Topoisomerase III alpha

Information d'application

Indications d'application: WB (H) 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TOP3A

Antigène: TOP3A (Topoisomerase (DNA) III alpha (TOP3A))

Autre désignation: Topoisomerase III alpha (TOP3A Produits)

Synonymes: anticorps TOP3, anticorps DNA topoisomerase III alpha, anticorps topoisomerase (DNA) III alpha, anticorps Top3a, anticorps TOP3A

Sujet: DNA topoisomerase 3-alpha (TOP3A) is an essential component of the RMI complex, a complex involves in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. It releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.

Poids moléculaire: 112 kDa

ID gène: 21975

NCBI Accession: NP_033436

UniProt: O70157

Pathways: Réparation de l'ADN