PD-1 anticorps (APC-iFluor™700)

N° du produit ABIN7076773

Détail du produit anti-PD-1 anticorps (APC-iFluor™700)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est conjugé à/à la APC-iFluor™700

Application: Flow Cytometry (FACS)

Pureté: >95 %

Classe de qualité: GMP Grade

Immunogène: PD1 transfected HEK293 cells

Clone: 8G10

Isotype: IgG1 kappa

Information d'application

Indications d'application: FC: 5 µL/test We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.2, 0.09 % sodium azide and 0.2 % (w/v) BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: PD1 (PDCD1 Produits)

Synonymes: anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1

Sujet: The clone 8G10, a mouse monoclonal antibody selectively binds with a 50-55 kD cell surface protein commonly known as Programmed cell death 1 (PD-1) or CD279, a member of the immunoglobulin superfamily. PD-1 expression is mostly observed in activated T cells and B cells, and also in dendritic cells. PD-1 signals via binding its two ligands, PD-L1 and PD-L2. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T cell death. Blocking of PD-1 by its antibody restores T cells immunity against tumor and infectious agents. PD-1-blockade based immunotherapy is, therefore, highly clinically useful against various types of cancers and infectious diseases.

ID gène: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints