RBCK1 anticorps

N° du produit ABIN7091633

Détail du produit anti-RBCK1 anticorps

Antigène: RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RBCK1 est non-conjugé

Application: Western Blotting (WB)

Homologie: Human

Immunogène: Recombinant human RBCK1 (UBCE7IP3).

Clone: R5E2

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RBCK1

Antigène: RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))

Autre désignation: RBCK1 (RBCK1 Produits)

Synonymes: anticorps RBCK1, anticorps C20orf18, anticorps HOIL-1, anticorps HOIL1, anticorps RBCK2, anticorps RNF54, anticorps UBCE7IP3, anticorps XAP3, anticorps XAP4, anticorps ZRANB4, anticorps C20ORF18, anticorps AL033326, anticorps HOIL-1L, anticorps UIP28, anticorps Ubce7ip3, anticorps Pkcbpb15, anticorps zgc:91964, anticorps SHANK-associated RH domain interactor, anticorps RANBP2-type and C3HC4-type zinc finger containing 1, anticorps ranBP-type and C3HC4-type zinc finger-containing protein 1, anticorps RanBP-type and C3HC4-type zinc finger containing 1, anticorps SHARPIN, anticorps RBCK1, anticorps LOC100411512, anticorps Rbck1, anticorps rbck1

Sujet:

Synonyms: C20orf18, HOIL1_HUMAN, RanBP-type and C3HC4-type zinc finger-containing protein 1, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, HOIL-1, Hepatitis B virus X-associated protein 4, RING finger protein 54, RING-type E3 ubiquitin transferase HOIL-1, Ubiquitin-conjugating enzyme 7-interacting protein 3, RNF54, UBCE7IP3, XAP3, XAP4.

Background: Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.

ID gène: 10616

UniProt: Q9BYM8