MCC anticorps
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- Antigène Voir toutes MCC Anticorps
- MCC (Mutated in Colorectal Cancers (MCC))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MCC est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Purification
- Immunogen affinity purified
- Pureté
- ≥95 % as determined by SDS-PAGE
- Immunogène
- mutated in colorectal cancers
- Isotype
- IgG
- Top Product
- Discover our top product MCC Anticorps primaire
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- Indications d'application
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Date de péremption
- 12 months
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- Antigène
- MCC (Mutated in Colorectal Cancers (MCC))
- Autre désignation
- MCC (MCC Produits)
- Synonymes
- anticorps MCC, anticorps mcc1, anticorps MCC1, anticorps D18Ertd451e, anticorps E330037C19, anticorps RGD1561988, anticorps mutated in colorectal cancers, anticorps MCC, anticorps mcc, anticorps Mcc
- Sujet
- Synonyms: Background:Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).
- Poids moléculaire
- 98 kDa , 113-118 kDa
- ID gène
- 4163
- UniProt
- P23508
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