PDK2 anticorps (AA 47-181)

N° du produit ABIN7118159

L’anticorps Lapin Polyclonal anti-PDK2 a été validé pour WB, IHC, ELISA et IP. Il convient pour détecter PDK2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PDK2 anticorps (AA 47-181) (ABIN7118159)

Antigène: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Détail du produit anti-PDK2 anticorps

Épitope: AA 47-181

Fonction: PDK2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 47-181aa

Immunogen: pyruvate dehydrogenase kinase, isozyme 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PDK2

Antigène: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Autre désignation: PDK2

Sujet:

Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial|Pyruvate dehydrogenase kinase isoform 2 (PDH kinase 2, PDKII)|PDK2|PDHK2

Background: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Poids moléculaire: 46 kDa

ID gène: 5164

UniProt: Q15119

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg