anticorps FLJ21127, anticorps JBTS13, anticorps TECT1, anticorps G730031O11Rik, anticorps Tect1, anticorps RGD1566266, anticorps tectonic family member 1, anticorps tectonic family member 1 L homeolog, anticorps TCTN1, anticorps tctn1.L, anticorps tctn1, anticorps Tctn1
Sujet
Synonyms:TECT1 Background:Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog(Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23(By similarity).