ITGAV/ITGB6 anticorps

N° du produit ABIN7127264

Détail du produit anti-ITGAV/ITGB6 anticorps

Antigène: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGAV/ITGB6 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunoprecipitation (IP), Coating (Coat), Immunofluorescence (IF)

Specificité: Integrins are heterodimers composed of noncovalently associated transmembrane i± and i² subunits. The 16 i± and 8 i² subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Mouse fibroblasts retrovirally infected with cDNA to human beta6, Cells expressed a mouse/human avb6 chimera.

Isotype: IgG2a

Information d'application

Indications d'application:

Known_Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA), Immunoprecipitation (1-2 μg/500 μg protein), ,Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1 μg/mL),Optimal dilution for a specific application should be determined.

Positive_Control: Squamous cell carcinoma cells. A375M melanoma cell line. A549 cell line.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur ITGAV/ITGB6

Antigène: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Autre désignation: ITGAV & ITGB6 (ITGAV/ITGB6 Produits)

Sujet: Antigen identified by monoclonal antibody L230, CD 51, CD51, Integrin alpha five, integrin alpha V beta 3, Integrin alpha-V light chain, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITGAV, MSK 8, Msk8, Vitronectin receptor subunit alpha, VNRA, VTNR, ITGB6, Integrin, beta 6,Integrin alpha V + beta 6
Cellular localisation: Membrane.

Poids moléculaire: 150-160kDa under non-reducing conditions. Under reducing conditions, cleaved into 2 bands of ~125-130kDa +20-25kDa

ID gène: 3685, 3694, 436873

UniProt: P06756, P18564