CAMK4 anticorps (pThr196, pThr200)

N° du produit ABIN7138796

Détail du produit anti-CAMK4 anticorps

Antigène: CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))

Épitope: pThr196, pThr200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAMK4 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 200 (M-K-T(p)-V-C) derived from Human CaMK4 or threonine 196 (M-K-T(p)-V-C) derived from Mouse CaMK4.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CAMK4

Antigène: CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))

Autre désignation: CAMK4 (CAMK4 Produits)

Synonymes: anticorps CaMK IV, anticorps CaMK-GR, anticorps IV, anticorps caMK, anticorps CAMK4, anticorps A430110E23Rik, anticorps AI666733, anticorps CaMKIV, anticorps CaMKIV/Gr, anticorps D18Bwg0362e, anticorps Ccdpk, anticorps RATCCDPK, anticorps camk4-A, anticorps wu:fj42a03, anticorps zgc:110275, anticorps calcium/calmodulin dependent protein kinase IV, anticorps calcium/calmodulin-dependent protein kinase IV, anticorps calcium/calmodulin-dependent protein kinase IV L homeolog, anticorps CAMK4, anticorps Camk4, anticorps camk4.L, anticorps camk4

Sujet:

Background:

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2).

Oury F, et al. (2010)Genes Dev 24, 2330-42. Dias WB, Cheung WD, Wang Z, Hart GW (2009) J Biol Chem 284, 21327-37. Chow FA, Anderson KA, Noeldner PK, Means AR (2005)J Biol Chem 280, 20530-8.

Aliases: Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody, Brain Ca(2+) calmodulin dependent protein kinase type IV antibody, Brain Ca++-calmodulin dependent protein kinase type IV antibody, Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody, Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody, Calcium/calmodulin dependent protein kinase IV antibody, Calcium/calmodulin dependent protein kinase type IV antibody, Calcium/calmodulin-dependent protein kinase type IV antibody, CAM kinase 4 antibody, CAM kinase GR antibody, CAM kinase IV antibody, CAM kinase-GR antibody, CaMK 4 antibody, CAMK GR antibody, CaMK IV antibody, Camk4 antibody, CaMKGR antibody, IV antibody, KCC4_HUMAN antibody, MGC36771 antibody

UniProt: Q16566

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma