CAMK2D anticorps (pThr287)

N° du produit ABIN7138827

Détail du produit anti-CAMK2D anticorps

Antigène: CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))

Épitope: pThr287

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAMK2D est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of Threonine 287(Q-E-T(p)-V-E) derived from Human CaMK2- beta/ gamma/ delta.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CAMK2D

Antigène: CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))

Autre désignation: CAMK2B/CAMK2G/CAMK2D (CAMK2D Produits)

Synonymes: anticorps CAMKD, anticorps CAMK1, anticorps Camk2, anticorps Camki, anticorps RATCAMKI, anticorps camk2, anticorps camkd, anticorps camkII, anticorps 2810011D23Rik, anticorps 8030469K03Rik, anticorps [d]-CaMKII, anticorps mKIAA4163, anticorps calcium/calmodulin dependent protein kinase II delta, anticorps calcium/calmodulin-dependent protein kinase II delta, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II delta S homeolog, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II delta, anticorps calcium/calmodulin-dependent protein kinase II, delta, anticorps CAMK2D, anticorps Camk2d, anticorps camk2d.S, anticorps camk2d

Sujet:

Background: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Aliases: Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody, Calcium/calmodulin dependent protein kinase II beta antibody, Calcium/calmodulin dependent protein kinase IIB antibody, Calcium/calmodulin dependent protein kinase type II beta chain antibody, calcium/calmodulin-dependent protein kinase II beta antibody, Calcium/calmodulin-dependent protein kinase type II subunit beta antibody, CAM 2 antibody, CaM kinase II beta chain antibody, CaM kinase II beta subunit antibody, CaM kinase II subunit beta antibody, CaM-kinase II beta chain antibody, CAM2 antibody, CAMK 2 antibody, CAMK 2B antibody, CaMK II beta subunit antibody, CaMK II subunit beta antibody, CaMK-II subunit beta antibody, CAMK2 antibody, CaMK2 beta antibody, Camk2b antibody, CAMKB antibody, CaMKII beta subunit antibody, CaMKIIB antibody, KCC2B_HUMAN antibody, MGC29528 antibody, Proline rich calmodulin dependent protein kinase antibody, proline rich calmodulin-dependent protein kinase antibody

UniProt: Q13554

Pathways: Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration