Glycogen Synthase Kinase 3 (GSK3) (pTyr216), (pTyr279) anticorps

N° du produit ABIN7138967

Détail du produit

Antigène: Glycogen Synthase Kinase 3 (GSK3)

Épitope: pTyr216, pTyr279

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3alpha/beta .

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Glycogen Synthase Kinase 3 (GSK3)

Autre désignation: GSK3A/GSK3B (GSK3 Produits)

Synonymes: anticorps GSK3, anticorps GSK-3, anticorps C86142, anticorps GSK-3beta, anticorps 7330414F15Rik, anticorps 8430431H08Rik, anticorps CG2621, anticorps DMSGG3, anticorps DMZ3K25Z, anticorps Dm Zw3, anticorps Dmel\CG2621, anticorps Dmsgg3, anticorps EG:155E2.3, anticorps EG:BACR7C10.8, anticorps GSK, anticorps GSK-3B, anticorps GSK-3betaSgg, anticorps GSK3-beta, anticorps GSK3A, anticorps GSK3Beta, anticorps GSK3beta, anticorps GSK3beta/SGG, anticorps GSK3betagr, anticorps GSKbeta, anticorps Gsk-3, anticorps Gsk-3beta, anticorps Gsk3, anticorps SGG, anticorps SGG/GSK3b, anticorps Sgg, anticorps Sgg/GSK-3b, anticorps Sgg/Zw3/GSK3, anticorps ZW-3, anticorps ZW3, anticorps Zw-3, anticorps Zw3, anticorps Zw3-sh, anticorps Zw3/GSK3, anticorps Zw3[sgg], anticorps anon-WO03040301.254, anticorps gsk3, anticorps l(1)3Ba, anticorps l(1)G0055, anticorps l(1)G0183, anticorps l(1)G0263, anticorps l(1)G0335, anticorps l(1)zw3, anticorps sgg-zw3, anticorps sgg/zw3, anticorps sgg10, anticorps sgg39, anticorps sgg46, anticorps zw-3, anticorps zw3, anticorps zw3(sgg), anticorps zw3/GSK3beta, anticorps zw3/sgg, anticorps zw3[sgg], anticorps zw[3], anticorps glycogen synthase kinase 3 beta, anticorps shaggy, anticorps Gsk3b, anticorps sgg

Sujet:

Background: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13, 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02, 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26, 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov, 2(11): 1215-1222

Aliases: Factor A, GSK-3 alpha/beta, kinase GSK3-alpha/beta

UniProt: P49840, P49841