26S Proteasome Complex Subunit SEM1 (SEM1) (AA 1-70) anticorps

N° du produit ABIN7348617

Détail du produit

Antigène: 26S Proteasome Complex Subunit SEM1 (SEM1)

Épitope: AA 1-70

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: 26S Proteasome Complex Subunit SEM1 (SEM1)

Autre désignation: SEM1

Sujet:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.

Aliases: SEM1 antibody, C7orf76 antibody, DSS1 antibody, SHFDG1 antibody, SHFM1 antibody, 26S proteasome complex subunit SEM1 antibody, 26S proteasome complex subunit DSS1 antibody, Deleted in split hand/split foot protein 1 antibody, Split hand/foot deleted protein 1 antibody, Split hand/foot malformation type 1 protein antibody

UniProt: P60896