PRKAG1 anticorps (AA 1-331) (Biotin)

N° du produit ABIN7142668

Détail du produit anti-PRKAG1 anticorps (Biotin)

Antigène: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Épitope: AA 1-331

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAG1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human 5\'-AMP-activated protein kinase subunit gamma-1 protein (1-331AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRKAG1

Antigène: PRKAG1 (Protein Kinase, AMP-Activated, gamma 1 Non-Catalytic Subunit (PRKAG1))

Autre désignation: PRKAG1 (PRKAG1 Produits)

Synonymes: anticorps MGC68503, anticorps zgc:63896, anticorps wu:fa94d09, anticorps wu:fd12h04, anticorps AMPKG, anticorps Prkaac, anticorps Prkga1, anticorps AA571379, anticorps BB036179, anticorps protein kinase, AMP-activated, gamma 1 non-catalytic subunit S homeolog, anticorps protein kinase, AMP-activated, gamma 1 non-catalytic subunit, anticorps protein kinase AMP-activated non-catalytic subunit gamma 1, anticorps prkag1.S, anticorps prkag1, anticorps PRKAG1, anticorps Prkag1

Sujet:

Background: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Aliases: 5' AMP activated protein kinase gamma 1 subunit antibody, 5' AMP activated protein kinase subunit gamma 1 antibody, 5''-AMP-activated protein kinase subunit gamma-1 antibody, AAKG1_HUMAN antibody, AMP activated protein kinase noncatalytic gamma 1 subunit antibody, AMPK gamma 1 chain antibody, AMPK gamma1 antibody, AMPK subunit gamma-1 antibody, AMPKg antibody, MGC8666 antibody, PRKAG 1 antibody, PRKAG1 antibody, Protein kinase AMP activated gamma 1 non catalytic subunit antibody, protein kinase, AMP-activated, noncatalytic gamma-1 antibody

UniProt: P54619

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process, L'effet Warburg