FZD7 anticorps (Frizzled Family Receptor 7) (AA 550-574) (HRP)

Details for Product anti-FZD7 Antibody No. ABIN710060
Antigène
  • FzE3
  • Fz-7
  • Xfz7
  • frizzled-7
  • frizzled7
  • frz-7
  • frz7
  • fz7
  • fzd7-a
  • fzd7-b
  • fze3
  • Fz7
  • cFz-7
  • fb38g02
  • fc44b09
  • fz13
  • fz7a
  • fz7b
  • wu:fb38g02
  • wu:fc44b09
  • zg13
  • frizzled class receptor 7
  • frizzled class receptor 7 L homeolog
  • frizzled class receptor 7b
  • FZD7
  • fzd7.L
  • fzd7
  • Fzd7
  • fzd7b
Épitope
AA 550-574
24
19
14
12
10
8
8
7
6
2
2
2
2
2
2
2
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
103
83
25
6
5
4
4
3
2
2
1
1
1
1
Hôte
Lapin
108
12
11
7
Clonalité
Polyclonal
Conjugué
Cet anticorp FZD7 est conjugé à/à la HRP
9
5
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
101
63
20
18
13
12
4
2
2
1
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human Frizzled 7
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others FZD7 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Frizzled 7
Sujet

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location: Cytoplasm

Synonyms: FzE3, Frizzled-7, Fz-7, hFz7, FZD7

ID gène 8324
UniProt O75084
Pathways Signalisation WNT, Stem Cell Maintenance
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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