AAK1 anticorps (AA 274-465)

N° du produit ABIN7367260

Détail du produit anti-AAK1 anticorps

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Épitope: AA 274-465

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AAK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AAK1

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Autre désignation: AAK1 (AAK1 Produits)

Synonymes: anticorps 5530400K14Rik, anticorps 9630042K20, anticorps AU067724, anticorps AU067726, anticorps BC028270, anticorps C79663, anticorps D6Ertd245e, anticorps R75501, anticorps mKIAA1048, anticorps RGD1563580, anticorps aak1, anticorps si:dkey-261l11.5, anticorps AP2 associated kinase 1, anticorps uncharacterized protein FLJ45252, anticorps AP2 associated kinase 1b, anticorps AAK1, anticorps Aak1, anticorps LOC100512341, anticorps aak1b

Sujet:

Background: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Aliases: AAK 1 antibody, Aak1 antibody, AAK1_HUMAN antibody, Adaptor associated kinase 1 antibody, Adaptor-associated kinase 1 antibody, AP2 associated kinase 1 antibody, AP2 associated protein kinase 1 antibody, AP2-associated protein kinase 1 antibody, DKFZp686F03202 antibody, DKFZp686K16132 antibody, FLJ23712 antibody, FLJ25931 antibody, FLJ31060 antibody, FLJ42882 antibody, FLJ45252 antibody, KIAA1048 antibody, MGC138170 antibody, MGC164568 antibody, MGC164570 antibody

UniProt: Q2M2I8