RAD1 anticorps (AA 1-282)

N° du produit ABIN7362003

Détail du produit anti-RAD1 anticorps

Antigène: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Épitope: AA 1-282

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Cell cycle checkpoint protein RAD1 protein (1-282AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RAD1

Antigène: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Autre désignation: RAD1 (RAD1 Produits)

Synonymes: anticorps HRAD1, anticorps REC1, anticorps zgc:56502, anticorps zgc:77779, anticorps RAD1, anticorps xrad1, anticorps DKFZp459H1127, anticorps RAD1 checkpoint DNA exonuclease, anticorps RAD1 homolog (S. pombe), anticorps RAD1, anticorps Rad1, anticorps rad1

Sujet:

Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\\\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3\\\'->5\\\' double stranded DNA exonuclease activity.

Aliases: Cell cycle checkpoint protein Hrad1 antibody, Cell cycle checkpoint protein Rad 1 A / B antibody, Cell cycle checkpoint protein RAD1 antibody, Checkpoint control protein HRAD1 antibody, Checkpoint control protein RAD1 antibody, DNA repair exonuclease antibody, DNA repair exonuclease rad1 antibody, DNA repair exonuclease rad1 homolog antibody, DNA repair exonuclease REC1 antibody, DNA repair protein RAD1 antibody, EC 3.1.11.2 antibody, Exonuclease homolog RAD1 antibody, GTP-binding protein RAD antibody, hRAD 1 antibody, hRAD1 antibody, MGC77779 antibody, RAD 1 antibody, RAD antibody, RAD1 antibody, RAD1 homolog (S. pombe) antibody, RAD1 homolog antibody, Rad1 like DNA damage checkpoint antibody, Rad1 like DNA damage checkpoint protein antibody, RAD1, S. pombe, homolog of antibody, Rad1-like DNA damage checkpoint protein antibody, RAD1_HUMAN antibody, Ras associated with diabetes antibody, REC 1 antibody, REC1 antibody, RRAD antibody

UniProt: O60671

Pathways: M Phase