TRKB anticorps (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (pTyr705)

Details for Product anti-NTRK2 Antibody No. ABIN710861
Antigène
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic receptor tyrosine kinase 2
  • neurotrophic receptor tyrosine kinase 2 L homeolog
  • neurotrophic tyrosine kinase, receptor, type 2b
  • neurotrophic receptor tyrosine kinase 2 S homeolog
  • neurotrophic tyrosine kinase, receptor, type 2
  • NTRK2
  • ntrk2.L
  • ntrk2b
  • ntrk2.S
  • ntrk2
  • Ntrk2
Épitope
pTyr705
27
26
19
16
16
16
15
14
12
11
11
10
9
8
8
7
6
6
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
301
217
205
12
11
9
8
6
3
2
Hôte
Lapin
300
23
9
5
2
Clonalité
Polyclonal
Conjugué
Cet anticorp TRKB est non-conjugé
11
8
8
8
8
8
8
5
5
4
3
3
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
227
130
114
47
43
30
26
12
8
3
1
1
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from rat NTRK2 around the phosphorylation site of Tyr705
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others TRKB products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Trkb (NTRK2 Antibody Extrait)
Sujet

The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

Synonyms: TrkB Tyr705, NTRK2Tyr705, NTRK2phospho Y705, TrkB, Tyrosine Receptor Kinase B, Tyrosine kinase,Pyk2, BDNF tropomyosine receptor kinase B, BDNF/NT 3 growth factors receptor, BDNF/NT-3 growth factors receptor, Brain derived neurotrophic factor receptor, GP145 TrkB, GP145-TrkB, GP145-TrkB/GP95-TrkB, GP95 TrkB, Neurotrophic tyrosine kinase receptor type 2, Neurotrophin receptor tyrosine kinase type 2, NTRK 2, Ntrk2, NTRK2_HUMAN, Obesity, hyperphagia, and developmental delay, included, RATTRKB1, Tkrb, Trk B, Trk-B, TRKB, TrkB tyrosine kinase, TRKB1, tyrosine kinase receptor B, Tyrosine receptor kinase B.

ID gène 4915
Pathways Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
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