Parkin anticorps (AA 1-465)

N° du produit ABIN7151093

Détail du produit anti-Parkin anticorps

Antigène: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Épitope: AA 1-465

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Parkin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase parkin protein (1-465AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Parkin

Antigène: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Autre désignation: PRKN (PARK2 Produits)

Synonymes: anticorps CG10523, anticorps Dmel\\CG10523, anticorps Dpark, anticorps SD01679, anticorps dpk, anticorps AR-JP, anticorps LPRS2, anticorps PDJ, anticorps PRKN, anticorps Park, anticorps Prkn, anticorps si:ch211-123f21.1, anticorps zgc:112390, anticorps pdr-1, anticorps PARK2, anticorps parkin, anticorps parkin RBR E3 ubiquitin protein ligase, anticorps Parkinson disease (autosomal recessive, juvenile) 2, parkin, anticorps park, anticorps PRKN, anticorps Prkn, anticorps prkn, anticorps CpipJ_CPIJ014867, anticorps Park2

Sujet:

Background: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as \\\'Lys-48\\\'-linked and \\\'Lys-63\\\'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating \\\'Lys-63\\\'-linked polyubiquitination of misfolded proteins such as PARK7: \\\'Lys-63\\\'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates \\\'Lys-63\\\'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates \\\'Lys-48\\\'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome, possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Aliases: AR JP antibody, E3 ubiquitin ligase antibody, E3 ubiquitin protein ligase parkin antibody, E3 ubiquitin-protein ligase parkin antibody, FRA6E antibody, LPRS 2 antibody, LPRS2 antibody, PARK 2 antibody, Park2 antibody, Parkin 2 antibody, Parkinson disease (autosomal recessive juvenile) 2 antibody, Parkinson disease (autosomal recessive, juvenile) 2, parkin antibody, Parkinson disease protein 2 antibody, Parkinson juvenile disease protein 2 antibody, Parkinson protein 2 E3 ubiquitin protein ligase antibody, Parkinson protein 2, E3 ubiquitin protein ligase (parkin) antibody, PDJ antibody, PRKN 2 antibody, PRKN antibody, PRKN2 antibody, PRKN2_HUMAN antibody, Ubiquitin E3 ligase PRKN antibody

UniProt: O60260

Pathways: Autophagy, Ubiquitin Proteasome Pathway