EPM2A anticorps (AA 244-331)

N° du produit ABIN7157845

Détail du produit anti-EPM2A anticorps

Antigène: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Épitope: AA 244-331

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPM2A est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Laforin protein (244-331AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPM2A

Antigène: EPM2A (Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A))

Autre désignation: EPM2A (EPM2A Produits)

Synonymes: anticorps TG-B, anticorps Tg(TcraK,TcrbK)TG-BFlv, anticorps EPM2, anticorps MELF, anticorps laforin, anticorps EPM2A, laforin glucan phosphatase, anticorps epilepsy, progressive myoclonic epilepsy, type 2 gene alpha, anticorps EPM2A, anticorps Epm2a

Sujet:

Background: Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.

Aliases: Epilepsy progressive myoclonus type 2 Lafora disease (laforin) antibody, Epilepsy progressive myoclonus type 2A Lafora disease (laforin) antibody, EPM2 antibody, Epm2a antibody, Epm2a gene antibody, EPM2A_HUMAN antibody, Lafora PTPase antibody, Laforin antibody, LAFPTPase antibody, LD antibody, LDE antibody, MELF antibody, RP3-466P17.2 antibody

UniProt: O95278

Pathways: Cellular Glucan Metabolic Process