PPM1A anticorps (pSer375)

N° du produit ABIN711761

Détail du produit anti-PPM1A anticorps

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Épitope: pSer375

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPM1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Dog,Cow,Sheep,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PPM1A around the phosphorylation site of Ser375

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PPM1A

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Autre désignation: PPM1A (PPM1A Produits)

Synonymes: anticorps PP2C-ALPHA, anticorps PP2CA, anticorps PP2Calpha, anticorps pp2ca1, anticorps ppp1r13b, anticorps si:ch211-253p18.1, anticorps wu:fd42g12, anticorps zgc:153820, anticorps 2310003C21Rik, anticorps 2900017D14Rik, anticorps AI427932, anticorps AU017636, anticorps MMPa-2, anticorps MPPa-1, anticorps Pp2c1, anticorps pp2c-alpha, anticorps pp2ca, anticorps pp2calpha, anticorps pp2ca2, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Ab, anticorps protein phosphatase 1A, magnesium dependent, alpha isoform, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Aa, anticorps PPM1A, anticorps ppm1ab, anticorps Ppm1a, anticorps ppm1a.L, anticorps ppm1aa

Sujet:

Synonyms: PPM1Aphospho S375, Mpp alpha, PP2C alpha, PP2C-alpha, PP2CA, PPM 1A, PPM1A, PPM1A_HUMAN, PPPM1A, Protein phosphatase 1A formerly 2C magnesium dependent alpha isoform, Protein phosphatase 1A, Protein phosphatase 1A magnesium dependent alpha, Protein phosphatase 2C alpha, Protein phosphatase 2C alpha isoform, Protein phosphatase 2C isoform alpha, Protein phosphatase IA, Protein phosphatase 2C isoform alpha, IA antibody.

Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

ID gène: 5494