WNT5A anticorps (AA 62-380)

N° du produit ABIN7166304

Détail du produit anti-WNT5A anticorps

Antigène: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Épitope: AA 62-380

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNT5A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protein Wnt-5a protein (62-380AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WNT5A

Antigène: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Autre désignation: WNT5A (WNT5A Produits)

Synonymes: anticorps hWNT5A, anticorps wnt-5A, anticorps wnt5a-B, anticorps WNT5A, anticorps 8030457G12Rik, anticorps Wnt-5a, anticorps Wnt family member 5A, anticorps Wnt family member 5A S homeolog, anticorps wingless-type MMTV integration site family, member 5a, anticorps wingless-type MMTV integration site family, member 5A, anticorps wingless-related MMTV integration site 5A, anticorps Wnt signaling ligand, anticorps WNT5A, anticorps Wnt5a, anticorps wnt5a.S, anticorps wnt5a, anticorps LOC578814, anticorps wnt5

Sujet:

Background: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Aliases: hWNT 5A antibody, hWNT5A antibody, Protein Wnt 5a antibody, Protein Wnt-5a antibody, Protein Wnt5a antibody, Wingless type MMTV integration site family member 5A antibody, Wnt 5a antibody, WNT 5A protein antibody, WNT 5A protein precursor antibody, WNT5A antibody, WNT5A protein precursor antibody, WNT5A_HUMAN antibody

UniProt: P41221

Pathways: Signalisation WNT, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size, Tube Formation