TRAF6 anticorps (AA 1-522)

N° du produit ABIN7172247

L’anticorps Lapin Polyclonal anti-TRAF6 a été validé pour IHC, ELISA et IF. Il convient pour détecter TRAF6 dans des échantillons de Humain.

Aperçu rapide pour TRAF6 anticorps (AA 1-522) (ABIN7172247)

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF6 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-TRAF6 anticorps

Épitope: AA 1-522

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human TNF receptor-associated factor 6 protein (1-522AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TRAF6

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Autre désignation: TRAF6

Sujet:

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of \\\'Lys-63\\\'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Aliases: E3 ubiquitin-protein ligase TRAF6 antibody, Interleukin 1 signal transducer antibody, Interleukin-1 signal transducer antibody, MGC 3310 antibody, MGC:3310 antibody, MGC3310 antibody, OTTHUMP00000232772 antibody, OTTHUMP00000232773 antibody, RING finger protein 85 antibody, RNF 85 antibody, RNF85 antibody, TNF receptor associated factor 6 antibody, TNF receptor-associated factor 6 antibody, TNF receptor-associated factor 6, E3 ubiquitin protein ligase antibody, TRAF 6 antibody, Traf6 antibody, TRAF6_HUMAN antibody

UniProt: Q9Y4K3

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway