SMUG1 anticorps

N° du produit ABIN7184184

Détail du produit anti-SMUG1 anticorps

Antigène: SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 (SMUG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMUG1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human SMUG1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SMUG1

Antigène: SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1 (SMUG1))

Autre désignation: SMUG1 (SMUG1 Produits)

Synonymes: anticorps SMUG1, anticorps xsmug1, anticorps 1200013B09Rik, anticorps A930006H09Rik, anticorps C85220, anticorps FDG, anticorps HMUDG, anticorps UNG3, anticorps single-strand-selective monofunctional uracil-DNA glycosylase 1, anticorps single-strand selective monofunctional uracil DNA glycosylase, anticorps single-strand-selective monofunctional uracil-DNA glycosylase 1 L homeolog, anticorps SMUG1, anticorps smug1, anticorps smuG1, anticorps smuG, anticorps LOC5577584, anticorps CpipJ_CPIJ002767, anticorps Smug1, anticorps smug1.L

Sujet:

Background: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.

Ide H., Biochemistry 42:5003-5012(2003).
Sugano S., Nat. Genet. 36:40-45(2004).
Venter J.C., Submitted (JUL-2005).

Aliases: FDG antibody, HMUDG antibody, MGC104370 antibody, Single strand selective monofunctional uracil DNA glycosylase 1 antibody, Single strand selective monofunctional uracil DNA glycosylase antibody, Single-strand selective monofunctional uracil DNA glycosylase antibody, SMUG 1 antibody, Smug1 antibody, SMUG1 protein antibody, SMUG1_HUMAN antibody, UNG 3 antibody, UNG3 antibody

UniProt: Q53HV7

Pathways: Réparation de l'ADN