ERN2 anticorps

N° du produit ABIN7190588

Détail du produit anti-ERN2 anticorps

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human ERN2

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:2000-1:5000, IHC:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ERN2

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Autre désignation: ERN2 (ERN2 Produits)

Synonymes: anticorps Ire1beta, anticorps ire1b, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps IRE1-BETA, anticorps IRE1b, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN2, anticorps ern2, anticorps Ern2

Sujet:

Background: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Aliases: ERN2 antibody, IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody, Endoplasmic reticulum-to-nucleus signaling 2 antibody, Inositol-requiring protein 2 antibody, hIRE2p antibody, Ire1-beta antibody, IRE1b) [Includes: Serine/threonine-protein kinase antibody, EC 2.7.11.1), Endoribonuclease antibody, EC 3.1.26.-)] antibody

UniProt: Q76MJ5