NSD1 anticorps

N° du produit ABIN7191723

Détail du produit anti-NSD1 anticorps

Antigène: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSD1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human NSD1

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:2000-1:5000, IHC:1:25-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NSD1

Antigène: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Autre désignation: NSD1 (NSD1 Produits)

Synonymes: anticorps NSD1, anticorps sto, anticorps kmt3b, anticorps sotos, anticorps ara267, anticorps ARA267, anticorps KMT3B, anticorps SOTOS, anticorps SOTOS1, anticorps STO, anticorps AI528500, anticorps nuclear receptor binding SET domain protein 1, anticorps histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, anticorps nuclear receptor-binding SET-domain protein 1, anticorps NSD1, anticorps nsd1, anticorps Nsd1, anticorps LOC540197

Sujet:

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Aliases: nuclear receptor binding SET domain protein 1

UniProt: Q96L73