PSMC1 anticorps (AA 77-440)

N° du produit ABIN7269584

Détail du produit anti-PSMC1 anticorps

Antigène: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Épitope: AA 77-440

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: PSMC1 Rabbit pAb

Séquence: EFIRNQEQMK PLEEKQEEER SKVDDLRGTP MSVGTLEEII DDNHAIVSTS VGSEHYVSIL SFVDKDLLEP GCSVLLNHKV HAVIGVLMDD TDPLVTVMKV EKAPQETYAD IGGLDNQIQE IKESVELPLT HPEYYEEMGI KPPKGVILYG PPGTGKTLLA KAVANQTSAT FLRVVGSELI QKYLGDGPKL VRELFRVAEE HAPSIVFIDE IDAIGTKRYD SNSGGEREIQ RTMLELLNQL DGFDSRGDVK VIMATNRIET LDPALIRPGR IDRKIEFPLP DEKTKKRIFQ IHTSRMTLAD DVTLDDLIMA KDDLSGADIK AICTEAGLMA LRERRMKVTN EDFKKSKENV LYKKQEGTPE GLYL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 77-440 of human PSMC1 (NP_002793.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PSMC1

Antigène: PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))

Autre désignation: PSMC1 (PSMC1 Produits)

Synonymes: anticorps AI325227, anticorps P26s4, anticorps S4, anticorps P26S4, anticorps p56, anticorps s4, anticorps protease (prosome, macropain) 26S subunit, ATPase 1, anticorps proteasome 26S subunit, ATPase 1, anticorps Psmc1, anticorps PSMC1

Sujet: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.,PSMC1,P26S4,S4,p56,ATPase 1,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,Ubiquitin,PSMC1

Poids moléculaire: 41kDa/49kDa

ID gène: 5700

UniProt: P62191

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway