RIPK1 anticorps

N° du produit ABIN7269886

Cet anticorps Lapin Monoclonal détecte spécifiquement RIPK1 dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour RIPK1 anticorps (ABIN7269886)

Antigène: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RIPK1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-RIPK1 anticorps

Fonction: RIPK1/RIP Rabbit mAb

Réactivité croisée: Humain

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human RIPK1/RIP.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RIPK1

Antigène: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Autre désignation: RIPK1

Sujet: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1 E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.,RIP,RIP-1,RIP1,RIPK1,Apoptosis,Apoptosis_Death receptors & ligands,Apoptosis_Inhibition of Apoptosis,Cancer,Cell Biology & Developmental Biology,Death Receptor Signaling Pathway,Immunology & Inflammation,Invasion and Metastasis,Kinase,Kinase_Serine/threonine kinases,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,NF-kB Signaling Pathway,Signal Transduction,Toll-like Receptor Signaling Pathway,RIPK1

Poids moléculaire: 75kDa

ID gène: 8737

UniProt: Q13546

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway