p53 anticorps

N° du produit ABIN7271080

Cet anticorps Lapin Monoclonal détecte spécifiquement p53 dans WB, IHC et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour p53 anticorps (ABIN7271080)

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Classe de qualité: KO Validated

Détail du produit anti-p53 anticorps

Fonction: [KO Validated] p53 Rabbit mAb

Réactivité croisée: Humain, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human p53.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: TP53

Sujet: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016],BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5,AMPK Signaling Pathway,Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Cell cycle inhibitors,DNA Damage & Repair,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,G1/S Checkpoint,G2/M DNA Damage Checkpoint,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Neurodegenerative Diseases,Neuroscience,PI3K-Akt Signaling Pathway,Protein phosphorylation,Signal Transduction,Transcription Factors,Tumor suppressors,Tumor suppressors_p53 pathway,Warburg Effect,TP53

Poids moléculaire: 53kDa

ID gène: 7157

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg